Histone lysine ubiquitination

Ubiquitination is a bulky modification to the small histone. Ubiquitination is achieved by ligation of the C-terminus of ubiquitin to the ε-amino group of the lysine residues. Each ubiquitin group adds 8.5 kDa to histones and provides signals important for gene regulation. Ubiquitination is catalyzed by a group of ligases named 'Lysine ubiquitinases'.


Download table as Excel
Sites of histone lysine ubiquitination
Site of modification Writers Erasers
H2AK119ub E3 ubiquitin-protein ligase RING2, E3 ubiquitin-protein ligase RING1 Histone H2A deubiquitinase MYSM1
H2AK121ub E3 ubiquitin-protein ligase RING2-
H2BK120ub E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase RBX1, E3 ubiquitin-protein ligase BRE1B-
H4K91ub E3 ubiquitin-protein ligase DTX3L-