Histone lysine ribosylation

Histone proteins often undergo ribosylation (ar) i.e. the addition of poly (ADP-ribose) units specifically at the lysine residues. This modification is mediated by Poly [ADP-ribose] polymerase (PARP) enzymes. ADP-ribose moiety adds ~560 Da to the histone protein and causes disruption of the nucleosome structure by the loss of histone-DNA interaction.


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Sites of histone lysine ribosylation
Site of modification Writers Erasers
H2AK13ar Poly [ADP-ribose] polymerase 1-
H2BK30ar Poly [ADP-ribose] polymerase 1-
H3K27ar Poly [ADP-ribose] polymerase 1-
H3K37ar Poly [ADP-ribose] polymerase 1-
H4K16ar Poly [ADP-ribose] polymerase 1-