Histone lysine biotinylation

Biotinylation (bio) on lysine residues is catalyzed by 'lysine biotinases'. A single biotin moiety contributes ~244 Dalton. Histone biotinylation is often enriched at heterochromatin and participates in gene silencing.


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Sites of histone lysine biotinylation
Site of modification Writers Erasers
H2AK125bio--
H2AK127bio--
H2AK129bio--
H2AK13bio--
H2AK9bio--
H3K18bio Biotin--protein ligase-
H3K9bio Biotin--protein ligase-
H4K12bio Biotin--protein ligase-
H4K8bio Biotin--protein ligase-