Histone arginine methylation

Histone arginines undergo mono (me1) or dimethylation (me2). S-adenosyl-L-methionine is the methyl donor. Histone arginine methylation is strongly associated with gene activation with the addition of ~14 daltons/methyl moiety.


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Sites of histone arginine methylation
Site of modification Writers Erasers
H2AR3me2 Protein arginine N-methyltransferase 6-
H3R17me1 Histone-arginine methyltransferase CARM1-
H3R17me2 Histone-arginine methyltransferase CARM1-
H3R26me1 Histone-arginine methyltransferase CARM1-
H3R2me1 Histone-arginine methyltransferase CARM1-
H3R2me2 Protein arginine N-methyltransferase 6 Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
H3R42me2--
H3R8me2 Protein arginine N-methyltransferase 5-
H4R3me1 Protein arginine N-methyltransferase 1 Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
H4R3me2 Protein arginine N-methyltransferase 5, Protein arginine N-methyltransferase 6, Protein arginine N-methyltransferase 1 Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6