Histone H2A

In human, there are eight H2A variants with significant difference in their size. These are coded by nine different genes that are present on different chromosomes. Different H2A variants e.g. MacroH2A, H2Abbd, H2A.X, H2A.Z, H2AJ are associated with specific function like X chromosome inactivation, transcriptional regulation, DNA damage, heat shock response, senescence etc.


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Variants of histone H2A
Variants (UniprotKB recommended name) UniprotKB Accession No. of coding gene(s)
Core histone macro-H2A.1 or Histone macroH2A1 or macroH2A1 or mH2A1O753671 (H2AFY)
Core histone macro-H2A.2 or Histone macroH2A2 or macroH2A2 or mH2A2Q9P0M61 (H2AFY2)
Histone H2A-Bbd type 2/3 or H2A.B.2 or H2A.B.3P0C5Z02 (H2AFB2, H2AFB3)
Histone H2A.J or H2a/jQ9BTM11 (H2AFJ)
Histone H2A.V or H2A.Z.2Q71UI91 (H2AFV)
Histone H2A.x or H2a/xP161041 (H2AFX)
Histone H2A.Z or H2A/zP0C0S51 (H2AFZ)
Histone H2A-Bbd type 1 or H2A.B.1 or H2A.BP0C5Y91 (H2AFB1)
Histone H2A.P or H2APO754091 (H2AP)