Histone H3

H3 has two isoforms, H3.1 and H3.2, coded by twelve genes. These are located on chromosome number 1 and 6. The functional role of various H3 isoforms PTMs has been studied in important cellular processes such as chromatin organisation, transcriptional regulation and cell cycle control etc.

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Isoform of histone H3
Isoform (UniprotKB recommended name) UniprotKB Accession No. of coding gene(s)
Histone H3.1P6843110 (H3C1/HIST1H3A, H3C4/HIST1H3D, H3C3/HIST1H3C, H3C6/HIST1H3E, H3C11/HIST1H3I, H3C8/HIST1H3G, H3C12/HIST1H3J, H3C10/HIST1H3H, H3C2/HIST1H3B, H3C7/HIST1H3F)
Histone H3.2Q71DI33 (H3C14/HIST2H3C, H3C15/HIST2H3A, H3C13/HIST2H3D)