Histone Lysine ribosylases

Poly (ADP-ribose) Polymerase (PARP) is the only reported enzyme that catalyzes the poly ADP-ribosylation of various nuclear proteins. PARP1 catalyzes the transfer of ADP-ribose group from nicotinamide adenine dinucleotide (NAD donor) to the lysine residue of histones or to an already existing poly (ADP-ribose) chain.

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Different histone Lysine ribosylases
Enzyme (UniprotKB recommended name) Coding gene/s Site of histone modification
Poly [ADP-ribose] polymerase 1PARP1H2AK13ar, H2BK30ar, H3K27ar, H3K37ar, H4K16ar

Epidrugs for ribosylasesPARPi