Histone Lysine methyltransferases

Lysine methyltransferases are the most widely studied and classified writers. These enzymes contain the evolutionarily conserved catalytic ‘SET domain’ and catalyze the transfer of methyl groups from S-Adenosyl methionine (SAM) to ε-amino group of target lysine residues. There are total thirty proteins reported in this class.

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Different histone Lysine methyltransferases
Enzyme (UniprotKB recommended name) Coding gene/s Site of histone modification
Histone-lysine N-methyltransferase EZH1EZH1H3K27me1, H3K27me2
Histone-lysine N-methyltransferase EZH2EZH2H3K27me1, H3K27me2, H3K27me3, H1K25me1
Histone-lysine N-methyltransferase MLLMLLH3K4me3
Histone-lysine N-methyltransferase MLL2MLL2
Histone-lysine N-methyltransferase MLL3MLL3H3K4me3
Histone-lysine N-methyltransferase MLL4UnknownH3K4me3
Histone-lysine N-methyltransferase MLL5MLL5
Histone-lysine N-methyltransferase NSD3WHSC1L1H3K4me2, H3K27me2, H3K27me3
Histone-lysine N-methyltransferase PRDM9PRDM9H3K4me3
Histone-lysine N-methyltransferase SETD1ASETD1AH3K4me3
Histone-lysine N-methyltransferase SETD1BSETD1BH3K4me3
Histone-lysine N-methyltransferase SETD2SETD2H3K36me3
Histone-lysine N-methyltransferase SETD7SETD7H3K4me1
Histone-lysine N-methyltransferase SETD8SETD8H4K20me1, H4K20me2
Histone-lysine N-methyltransferase SETDB1SETDB1H3K9me3
Histone-lysine N-methyltransferase SETDB2SETDB2H3K9me3
Histone-lysine N-methyltransferase SETMARSETMARH3K36me2
Histone-lysine N-methyltransferase SUV39H1SUV39H1H3K9me3
Histone-lysine N-methyltransferase SUV39H2SUV39H2H3K9me3
Histone-lysine N-methyltransferase SUV420H1SUV420H1H4K20me2, H4K20me3
Histone-lysine N-methyltransferase SUV420H2SUV420H2H4K20me2, H4K20me3
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificNSD1H3K36me2, H4K20me2
Histone-lysine N-methyltransferase, H3 lysine-79 specificDOT1LH3K79me1, H3K79me2, H3K79me3
Histone-lysine N-methyltransferase, H3 lysine-9 specific 3EHMT2H3K9me1, H3K9me2, H3K27me1, H1K186me1, H1K25me1
Histone-lysine N-methyltransferase, H3 lysine-9 specific 5EHMT1H3K9me2, H3K27me1, H1K25me1, H1K186me1
N-lysine methyltransferase SMYD2SMYD2H3K36me2
PR domain zinc finger protein 2PRDM2H3K9me2
Probable histone-lysine N-methyltransferase ASH1LASH1LH3K36me1, H3K36me2
Probable histone-lysine N-methyltransferase NSD2WHSC1H3K36me3, H4K20me1, H4K20me3
SET and MYND domain-containing protein 3SMYD3H3K4me3

Epidrugs for methyltransferasesHMTi DNMTi