Histone Lysine deubiquitinases

Ubiquitin moieties attached to the core histones are cleaved using a group of proteases called 'deubiquitinases'. There are 5 different deubiquitinases reported to be present in humans that recognize histones as substrates.

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Different histone Lysine deubiquitinases
Enzyme (UniprotKB recommended name) Coding gene/s Site of histone modification
Histone H2A deubiquitinase MYSM1MYSM1H2AK119ub
Lys-63-specific deubiquitinase BRCC36BRCC3
Ubiquitin carboxyl-terminal hydrolase 16USP16
Ubiquitin carboxyl-terminal hydrolase 22USP22
Ubiquitin carboxyl-terminal hydrolase 3USP3