Histone Lysine demethylases

Histone demethylases regulates gene expression by removal of methylation marks. There are total twenty lysine demethylases reported in literature.

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Different histone Lysine demethylases
Enzyme (UniprotKB recommended name) Coding gene/s Site of histone modification
Histone lysine demethylase PHF8PHF8H3K9me2, H3K4me3, H4K20me1, H3K27me2
Lysine-specific demethylase 2AKDM2AH3K36me2
Lysine-specific demethylase 2BKDM2BH3K4me3, H3K36me2
Lysine-specific demethylase 3AKDM3AH3K9me1, H3K9me2
Lysine-specific demethylase 3BKDM3BH3K9me1, H3K9me2
Lysine-specific demethylase 4AKDM4AH3K9me3, H3K36me3
Lysine-specific demethylase 4BKDM4BH3K9me3
Lysine-specific demethylase 4CKDM4CH3K9me2, H3K9me3
Lysine-specific demethylase 4DKDM4DH3K9me3, H3K9me2, H1K25me1
Lysine-specific demethylase 5AKDM5AH3K4me2, H3K4me3
Lysine-specific demethylase 5BKDM5BH3K4me3
Lysine-specific demethylase 5CKDM5CH3K4me3
Lysine-specific demethylase 5DKDM5DH3K4me3, H3K4me2
Lysine-specific demethylase 6AKDM6AH3K27me3
Lysine-specific demethylase 6BKDM6BH3K27me3, H3K27me2
Lysine-specific demethylase 7JHDM1DH3K9me2, H3K27me2
Lysine-specific demethylase 8JMJD5H3K36me2
Lysine-specific demethylase NO66C14orf169H3K4me3, H3K36me3
Lysine-specific histone demethylase 1AKDM1AH3K4me1, H3K4me2, H3K9me1, H3K9me2
Lysine-specific histone demethylase 1BKDM1BH3K9me2

Epidrugs for demethylasesHDMi