Histone Lysine biotinases

A single lysine biotinase is known in humans, it catalyzes the reaction in 2 steps: (i) activation of biotin by addition of AMP to give biotinyl-5'-AMP, utilizing ATP as a donor, (ii) transfer to histones via removal of AMP.

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Different histone Lysine biotinases
Enzyme (UniprotKB recommended name) Coding gene/s Site of histone modification
Biotin--protein ligaseHLCSH3K9bio, H3K18bio, H4K12bio, H4K8bio