Histone Lysine acetyltransferases

The acetylation of histones is mediated by Lysine acetyltransferases (KATs). They catalyze the transfer of acetyl group from acetyl-CoA to the ε-amino group of specific lysine residues. This neutralizes the positive charge of the lysines and hence the histone-DNA interaction is reduced. There are 19 proteins reported in humans that demonstrate the histone acetyltransferases activity.

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Different histone Lysine acetyltransferases
Enzyme (UniprotKB recommended name) Coding gene/s Site of histone modification
Bifunctional protein NCOATMGEA5H4K8ac, H3K14ac
Chromodomain Y-like proteinCDYL
Circadian locomoter output cycles protein kaputCLOCKH3K14ac
CREB-binding proteinCREBBPH3K27ac, H3K56ac, H3K18ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac
Elongator complex protein 3ELP3H3K9ac, H3K18ac
General transcription factor 3C polypeptide 4GTF3C4H3K14ac
Histone acetyltransferase KAT2AKAT2AH3K9ac, H3K14ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac, H4K91ac
Histone acetyltransferase KAT2BKAT2B
Histone acetyltransferase KAT5KAT5H4K5ac, H4K8ac, H4K12ac, H2AK5ac
Histone acetyltransferase MYST2MYST2H4K5ac, H4K8ac, H4K12ac
Histone acetyltransferase MYST3MYST3H3K14ac
Histone acetyltransferase MYST4MYST4
Histone acetyltransferase p300EP300H3K27ac, H3K56ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac, H3K18ac
Histone acetyltransferase type B catalytic subunitHAT1H4K5ac, H4K12ac, H2AK5ac
N-acetyltransferase 10NAT10
Nuclear receptor coactivator 1NCOA1
Nuclear receptor coactivator 3NCOA3
Probable histone acetyltransferase MYST1MYST1H4K16ac
Testis-specific chromodomain protein Y 1CDY1B, CDY1

Epidrugs for acetyltransferasesHATi PAHi