Histone Arginine methyltransferases

Arginine methylation is a function of protein arginine methyltransferases (PRMTs). There are 9 types of PRMTs found in humans but only seven are reported to methylate histones. They can mediate mono or dimethylation of arginine residues using S-adenosyl-methionine (SAM) as a methyl donor. Based on the position of methyl group addition, the PRMTs are classified into two types. Type I PRMTs that include CARM1, PRMT1, PRMT2, PRMT3, PRMT6 and PRMT8. Type II PRMTs which include PRMT5 and PRMT7.

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Different histone Arginine methyltransferases
Enzyme (UniprotKB recommended name) Coding gene/s Site of histone modification
Histone-arginine methyltransferase CARM1CARM1H3R17me1, H3R17me2, H3R2me1, H3R26me1
Protein arginine N-methyltransferase 1PRMT1H4R3me1, H4R3me2
Protein arginine N-methyltransferase 2PRMT2
Protein arginine N-methyltransferase 5PRMT5H3R8me2, H4R3me2
Protein arginine N-methyltransferase 6PRMT6H3R2me2, H4R3me2, H2AR3me2
Protein arginine N-methyltransferase 7PRMT7
Protein arginine N-methyltransferase 8PRMT8

Epidrugs for methyltransferasesHMTi DNMTi