Ribosomal protein S6 kinase alpha-4

It belongs to the AGC Ser/Thr protein kinase family. It is a mitogen and stress-activated kinase. It plays an important role to acquire environmental cues and mediate epigenetic changes.

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Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) infosheet
UniprotKB AccessionO75676
Alternative Name(s)90 kDa ribosomal protein S6 kinase 4, Nuclear mitogen- and stress-activated protein kinase 2, Ribosomal protein kinase B (RSKB)
Writer for PTM/s H3S28ph
EC number 2.7.11.1
No. of coding genesRibosomal protein S6 kinase alpha-4 is coded by following 1 non-allelic gene/s
Gene nameribosomal protein S6 kinase, 90kDa, polypeptide 4
Gene symbolRPS6KA4
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s-
AliasesRSK-B, MSK2
GeneID8986
HGNC10433
RefSeq mRNANM_003942.2
RefSeq ProteinNP_003933.1
TCGA Gene Expression (Firebrowse)RPS6KA4
mir TargetsRPS6KA4
PubmedFor more Information

Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2