Histone-lysine N-methyltransferase SETDB1

SETDB1 is part of a multimeric complex which comprises of various methyltransferases like Suv39h1, G9a and GLP (PMID: 20129054). It is known to form a complex consisting of HP1alpha-CAF1-SETDB1 which is involved in the methylation of H3K9 in the pericentric heterochromatin in DNA replication (PMID: 19498464) (PMID: 15327775).

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Histone-lysine N-methyltransferase SETDB1 infosheet
UniprotKB AccessionQ15047
Alternative Name(s)ERG-associated protein with SET domain (ESET), SET domain bifurcated 1
Writer for PTM/s H3K9me3
EC number 2.1.1.43
No. of coding genesHistone-lysine N-methyltransferase SETDB1 is coded by following 1 non-allelic gene/s
Gene nameSET domain, bifurcated 1
Gene symbolSETDB1
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s-
AliasesKG1T, KIAA0067, ESET, KMT1E
GeneID9869
HGNC10761
RefSeq mRNANM_001145415.1NM_012432.3
RefSeq ProteinNP_001138887.1NP_036564.3
TCGA Gene Expression (Firebrowse)SETDB1
mir TargetsSETDB1
PubmedFor more Information

Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3