Histone-lysine N-methyltransferase NSD3

WHISTLE is a histone methyltransferase involved in H3K4 and H3K27 methylation.

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Histone-lysine N-methyltransferase NSD3 infosheet
UniprotKB AccessionQ9BZ95
Alternative Name(s)Nuclear SET domain-containing protein 3, Protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1-like protein 1)
Writer for PTM/s H3K4me2, H3K27me2, H3K27me3
EC number 2.1.1.43
No. of coding genesHistone-lysine N-methyltransferase NSD3 is coded by following 1 non-allelic gene/s
Gene nameWolf-Hirschhorn syndrome candidate 1-like 1
Gene symbolWHSC1L1
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s-
AliasesFLJ20353, NSD3
GeneID54904
HGNC12767
RefSeq mRNANM_017778.2NM_023034.1
RefSeq ProteinNP_060248.2NP_075447.1
TCGA Gene Expression (Firebrowse)WHSC1L1
mir TargetsWHSC1L1
PubmedFor more Information

Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3