Histone-lysine N-methyltransferase MLL

MLL1 mediates H3K4 trimethylation and is known to associate with active transcription.

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Histone-lysine N-methyltransferase MLL infosheet
UniprotKB AccessionQ03164
Alternative Name(s)ALL-1, CXXC-type zinc finger protein 7, Lysine N-methyltransferase 2A (KMT2A), Trithorax-like protein, Zinc finger protein HRX
Writer for PTM/s H3K4me3
EC number 2.1.1.43
No. of coding genesHistone-lysine N-methyltransferase MLL is coded by following 1 non-allelic gene/s
Gene namemyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
Gene symbolMLL
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s-
AliasesTRX1, HRX, ALL-1, HTRX1, CXXC7, MLL1A, KMT2A
GeneID4297
HGNC7132
RefSeq mRNANM_005933.3
RefSeq ProteinNP_005924.2
TCGA Gene Expression (Firebrowse)MLL
mir TargetsMLL
PubmedFor more Information

Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3