Histone-lysine N-methyltransferase EZH2

Ezh2 is known for H3K27 methylation activity and is part of Polycomb group of repressor complex (PRC).

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Histone-lysine N-methyltransferase EZH2 infosheet
UniprotKB AccessionQ15910
Alternative Name(s)ENX-1, Enhancer of zeste homolog 2, Lysine N-methyltransferase 6
Writer for PTM/s H3K27me1, H3K27me2, H3K27me3, H1K25me1
EC number 2.1.1.43
No. of coding genesHistone-lysine N-methyltransferase EZH2 is coded by following 1 non-allelic gene/s
Gene nameenhancer of zeste homolog 2 (Drosophila)
Gene symbolEZH2
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s-
AliasesEZH1, ENX-1, KMT6, KMT6A
GeneID2146
HGNC3527
RefSeq mRNANM_004456.4NM_152998.2
RefSeq ProteinNP_004447.2NP_694543.1
TCGA Gene Expression (Firebrowse)EZH2
mir TargetsEZH2
PubmedFor more Information

Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3