Histone-lysine N-methyltransferase EZH2
Ezh2 is known for H3K27 methylation activity and is part of Polycomb group of repressor complex (PRC).
| UniprotKB Accession | Q15910 | |
|---|---|---|
| Alternative Name(s) | ENX-1, Enhancer of zeste homolog 2, Lysine N-methyltransferase 6 | |
| Writer for PTM/s | H3K27me1, H3K27me2, H3K27me3, H1K25me1 | |
| EC number | 2.1.1.43 | |
| No. of coding genes | Histone-lysine N-methyltransferase EZH2 is coded by following 1 non-allelic gene/s | |
| Gene name | enhancer of zeste homolog 2 (Drosophila) | |
| Gene symbol | EZH2 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | - | |
| Aliases | EZH1, ENX-1, KMT6, KMT6A | |
| GeneID | 2146 | |
| HGNC | 3527 | |
| RefSeq mRNA | NM_004456.4 | NM_152998.2 |
| RefSeq Protein | NP_004447.2 | NP_694543.1 |
| TCGA Gene Expression (Firebrowse) | EZH2 | |
| mir Targets | EZH2 | |
| Pubmed | For more Information | |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3