Histone-lysine N-methyltransferase, H3 lysine-79 specific

Dot1L is reported to be involved in H3K79 methylation.

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Histone-lysine N-methyltransferase, H3 lysine-79 specific infosheet
UniprotKB AccessionQ8TEK3
Alternative Name(s)DOT1-like protein, Histone H3-K79 methyltransferase (H3-K79-HMTase), Lysine N-methyltransferase 4
Writer for PTM/s H3K79me1, H3K79me2, H3K79me3
EC number 2.1.1.43
No. of coding genesHistone-lysine N-methyltransferase, H3 lysine-79 specific is coded by following 1 non-allelic gene/s
Gene nameDOT1-like, histone H3 methyltransferase (S. cerevisiae)
Gene symbolDOT1L
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s-
AliasesKIAA1814, DOT1, KMT4
GeneID84444
HGNC24948
RefSeq mRNANM_032482.2
RefSeq ProteinNP_115871.1
TCGA Gene Expression (Firebrowse)DOT1L
mir TargetsDOT1L
PubmedFor more Information

Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3