Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific

NSD1 is methyltransferase specific for H3K36 and H4K20 methylation.

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Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific infosheet
UniprotKB AccessionQ96L73
Alternative Name(s)Androgen receptor coactivator 267 kDa protein, Androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, Lysine N-methyltransferase 3B, Nuclear receptor-binding SET domain-containing protein 1 (NR-binding SET domain-containing protein)
Writer for PTM/s H3K36me2, H4K20me2
EC number 2.1.1.43
No. of coding genesHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific is coded by following 1 non-allelic gene/s
Gene namenuclear receptor binding SET domain protein 1
Gene symbolNSD1
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sSTO
AliasesARA267, FLJ22263, KMT3B
GeneID64324
HGNC14234
RefSeq mRNANM_022455.4NM_172349.2
RefSeq ProteinNP_071900.2NP_758859.1
TCGA Gene Expression (Firebrowse)NSD1
mir TargetsNSD1
PubmedFor more Information

Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3