Biotin--protein ligase

HCS catalyses the addition of biotin groups on histone H3 at lysine 9 and 18 position.

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Biotin--protein ligase infosheet
UniprotKB AccessionP50747
Alternative Name(s)Biotin apo-protein ligase
Writer for PTM/s H3K9bio, H3K18bio, H4K12bio, H4K8bio
EC number 6.3.4.-, 6.3.4.9, 6.3.4.10, 6.3.4.11, 6.3.4.15
No. of coding genesBiotin--protein ligase is coded by following 1 non-allelic gene/s
Gene nameholocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
Gene symbolHLCS
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s-
AliasesHCS
GeneID3141
HGNC4976
RefSeq mRNANM_000411.5
RefSeq ProteinNP_000402.3
TCGA Gene Expression (Firebrowse)HLCS
mir TargetsHLCS
PubmedFor more Information

Lysine biotinases Biotin--protein ligase