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Drug Name:
Category: PADi
Description: PAD4-specific inhibitor. It is selective over PAD1-3. It blocks citrulination of
target proteins of PAD4.
Synonyms:

Structural Information:
2D Image:
Structure 2D: Download
Molecular Formula: C27H32ClN5O3
Molecular Weight: 510.035 g/mol
IUPAC name: [(3S,4R)-3-amino-4-hydroxypiperidin-1-yl]-[2-[1-(cyclopropylmethyl)indol-2-yl]-7-methoxy-1-methylben
zimidazol-5-yl]methanone;hydrochloride
InChI: InChI=1S/C27H31N5O3.ClH/c1-30-25-20(11-18(13-24(25)35-2)27(34)31-10-9-23(33)19(2
8)15-31)29-26(30)22-12-17-5-3-4-6-21(17)32(22)14-16-7-8-16;/h3-6,11-13,16,19,23,
33H,7-10,14-15,28H2,1-2H3;1H/t19-,23+;/m0./s1
SMILES: CN1C2=C(C=C(C=C2OC)C(=O)N3CCC(C(C3)N)O)N=C1C4=CC5=CC=CC=C5N4
CC6CC6.Cl

Clinical Information:
FDA status: Experimental
FDA_UNII: -
Clinical Trials : Not recruiting
Clinical Trials


Bioassay Information: GSK484
Source: PubChem Bioassay database
No information available for GSK484


References:
Literature Reference: PMC4397581
Literature: Pubmed
Google Scholar
PubChem ID: 86340151
PubChem Citation: National Center for Biotechnology Information. PubChem Compound Database; CID=86340151, https://pubchem.ncbi.nlm.nih.gov/compound/86340151 (accessed Mar. 8, 2019).
ChEMBL ID: -
ZINC DB: -
LiverTox: Not available for GSK484
Human Metabolome database : HMDB