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Drug Name:
Category: PADi
Description: Cl-amidine- PADI , strongly affects the expression of several cell cycle genes
implicated in tumor progression, including p21, GADD45?, and Ki67.
Synonyms:

Structural Information:
2D Image:
Structure 2D: Download
Molecular Formula: C14H19ClN4O2
Molecular Weight: 310.782 g/mol
IUPAC name: N-[(2S)-1-amino-5-[(1-amino-2-chloroethylidene)amino]-1-oxopentan-2-yl]benzamide
InChI: InChI=1S/C14H19ClN4O2/c15-9-12(16)18-8-4-7-11(13(17)20)19-14(21)10-5-2-1-3-6-10/
h1-3,5-6,11H,4,7-9H2,(H2,16,18)(H2,17,20)(H,19,21)/t11-/m0/s1
SMILES: NC(=O)[C@H](CCCNC(=N)CCl)NC(=O)c1ccccc1

Clinical Information:
FDA status: Experimental
FDA_UNII: -
Clinical Trials : Not recruiting
Clinical Trials

Source: PubChem Bioassay
Bioassay Information
AID CID SID Assay Name Target GI Target GeneID Bioactivity Outcome
712879 24970878 163326132 Ratio of Kinact to Ki for PAD1 Unspecified
712880 24970878 163326132 Ratio of Kinact to Ki for PAD2 Unspecified
725673 24970878 163326132 Inhibition of PAD4 (unknown
origin)
296439260 23569 Active
1121825 24970878 163326132 Inhibition of
thapsigargin-induced cell
death in human HEK293T cells
overexpressing human
recombinant PAD3 assessed as
increase in cell survival at
100 uM treated 15 mins prior
to thapsigargin addition
measured after 24 hrs drug
treatment by methylene blue
assay
Active
1121829 24970878 163326132 Inhibition of
thapsigargin-induced cell
death in human NSC assessed as
increase in cell survival at
>10 uM treated 15 mins prior
to thapsigargin addition
measured after 24 hrs drug
treatment by methylene blue
assay
Active

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References:
Literature Reference: PMC3572853
Literature: Pubmed
Google Scholar
PubChem ID: 24970878
PubChem Citation: National Center for Biotechnology Information. PubChem Compound Database; CID=24970878, https://pubchem.ncbi.nlm.nih.gov/compound/24970878 (accessed Mar. 8, 2019).
ChEMBL ID: CHEMBL1962361
ZINC DB: -
LiverTox: Not available for Cl-amidine
Human Metabolome database : HMDB