H3K9me3

H3K9me3 has been well characterised as a mark of transcriptional repression. However, a study does suggest that it is also present at differentially expressed genes in cancers (PMID: 17968314). Reports suggest the presence of this site at silent as well as transcribed regions of the genome (PMID: 16061184). H3K9me3 is also important for transcriptional elongation of MHC II HLA-DRA genes (PMID: 17478518).


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H3K9me3 infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2
Eraser/s Lysine-specific demethylase 4A, Lysine-specific demethylase 4B, Lysine-specific demethylase 4C, Lysine-specific demethylase 4D
Disease associations
Metabolic disorder: Diabetes; PMID: 18579779
Neurological disorders: Fragile X syndrome; PMID: 20843831
Cancer: Acute myeloid leukaemia; PMID: 20498303
Pulmonary disorder: Idiopathic pulmonary fibrosis; PMID: 20404089
Muscle dystropy: Facioscapulohumeral dystrophy (FSHD); PMID: 19593370
Cancer: Melanoma; PMID: 21430779
Cancer: Chronic lymphocytic leukemia (CLL); PMID: 21062507
Neurological disorder: Huntington's disease; PMID: 17403718
Cancer: Acute myeloid leukaemia; PMID: 16861263
Cancer: Prostate cancer; PMID: 19739128

Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3