H2AS137ph

Macro H2A is found to be enriched on inactive X chromosome but its phosphorylation at S137 leads to the exclusion of this variant from the heterochromatic region, suggesting its unique role in chromatin regulation beyond X inactivation. S137 phosphorylation is enriched during mitosis phase. Thus suggesting its role in normal cell cycle progression (PMID: 18227505).


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H2AS137ph infosheet
Modified variants Core histone macro-H2A.1
Writer/s
Eraser/s
Disease associationsNo disease associations known for H2AS137ph

Sites of serine/threonine/tyrosine phosphorylation H1S171ph, H1S172ph, H1S17ph, H1S186ph, H1S188ph, H1S26ph, H1T10ph, H1T137ph, H1T145ph, H1T153ph, H1T154ph, H1T17ph, H1T30ph, H2AS137ph, H2AS139ph, H2AS1ph, H2AT120ph, H2AY142ph, H2BS14ph, H3S10ph, H3S28ph, H3S31ph, H3S6ph, H3T11ph, H3T3ph, H3T45ph, H3T6ph, H3Y41ph, H4S1ph