H2AK119ub

H2AK119 ubiquitination is linked to Polycomb mediated gene silencing (PMID: 15386022).


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H2AK119ub infosheet
Modified variants Histone H2A type 1, Histone H2A type 1-A, Histone H2A type 1-B/E, Histone H2A type 1-C, Histone H2A type 1-D, Histone H2A type 1-H, Histone H2A type 1-J, Histone H2A type 2-A, Histone H2A type 2-B, Histone H2A type 2-C, Histone H2A type 3, Histone H2A.x
Writer/s E3 ubiquitin-protein ligase RING1, E3 ubiquitin-protein ligase RING2
Eraser/s Histone H2A deubiquitinase MYSM1
Disease associations
Neurological disorder: Huntington's disease; PMID: 18400894

Sites of lysine ubiquitination H2AK119ub, H2AK121ub, H2BK120ub, H4K91ub