Histone Lysine biotinylation

Biotinylation (bio) on lysine residues is catalysed by 'lysine biotinases'. These marks are generally abundant in repressed regions of the chromatin. A single biotin moiety contributes ~244 Dalton. Histone biotinylation is often enriched at heterochromatin and participates in gene silencing.


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Sites of histone Lysine biotinylation
Site of modification Writers Erasers
H2AK125bio
H2AK127bio
H2AK129bio
H2AK13bio
H2AK9bio
H3K18bio Biotin--protein ligase
H3K9bio Biotin--protein ligase
H4K12bio Biotin--protein ligase
H4K8bio Biotin--protein ligase